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pemetrexed and platinum for elderly patients with advanced non-squamous non-small-cell lung cancer: a retrospectiveanalysis

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 610-617 doi: 10.1007/s11684-021-0827-8

Abstract: Thus, 59 patients were included in the present retrospective study, 22 patients in the bevacizumab plus

Keywords： bevacizumab     elderly patient     advanced non-small-cell lung cancer     overall survival     toxicity    

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Aortic aneurysm and chronic disseminated intravascular coagulation: a retrospective study of 235 patients

Yun Zhang,Chen Li,Min Shen,Bao Liu,Xuejun Zeng,Ti Shen

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 62-67 doi: 10.1007/s11684-017-0498-7

Abstract:

Chronic disseminated intravascular coagulation (DIC) is a rare but devastating complication of aortic aneurysm (AA). This study investigated the clinical manifestations, laboratory findings, and treatment of patients with AA-associated chronic DIC (AA-DIC) and explored the mechanisms, duration, and therapeutic response of AA-DIC. We retrospectively reviewed the medical records of 235 AA patients admitted at the Peking Union Medical College Hospital between September 2009 and January 2015. The patients were classified as those with DIC (AA-DIC) and those without DIC (non-DIC). The AA-DIC group showed a significantly higher proportion of female patients and a significantly longer AA disease course than the non-DIC group did. The AA-DIC patients presented mural thrombi, dissecting aneurysms, a family history of AA, and diabetes significantly more frequently than the non-DIC patients did. Furthermore, multiple regression analyses revealed that sex, mural thrombus, aneurysm type, diabetes, and stent surgery are possible independent risk factors for AA-DIC patients. Fifty-two (22.1%) patients presented AA-DIC. Among these patients, 43 had non-typical DIC and 9 had typical DIC; the mortality rate of the latter was 22.2%. The mean age of the patients with typical DIC was significantly higher than of that of patients with non-typical DIC. The non-typical DIC patients also presented abnormal coagulation disorders of varying degrees. Furthermore, heparin or low-molecular-weight heparin improved the clinical symptoms and laboratory parameters in patients with AA and typical DIC. Thus, chronic DIC should be considered in patients with AA.

Keywords： aortic aneurysm     disseminated intravascular coagulation     anticoagulation therapy    

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Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center retrospective

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 111-125 doi: 10.1007/s11684-021-0854-5

Abstract: In this multi-center, retrospective, and observational cohort study, 109 CHB and 327 non-CHB patients

Keywords： COVID-19     chronic hepatitis B     liver injury     coagulation dysfunction    

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infections among diarrheal outpatients in Shanghai: a retrospective case study

Yanyan Jiang, Zhongying Yuan, Guoqing Zang, Dan Li, Ying Wang, Yi Zhang, Hua Liu, Jianping Cao, Yujuan Shen

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 98-103 doi: 10.1007/s11684-018-0614-3

Abstract:

Cyclospora cayetanensis is a foodborne and waterborne pathogen that causes endemic and epidemic human diarrhea worldwide. A few epidemiological studies regarding C. cayetanensis infections in China have been conducted. During 2013, a total of 291 stool specimens were collected from patients with diarrhea at a hospital in urban Shanghai. C. cayetanensis was not detected in any of the stool specimens by traditional microscopy, whereas five stool specimens (1.72%, 5/291) were positive by PCR. These positive cases confirmed by molecular technology were all in the adult group (mean age 27.8 years; 2.94%, 5/170) with watery diarrhea. Marked infection occurred in the rainy season of May and July. Sequence and phylogenetic analyses of the partial 18S rRNA genes of C. cayetanensis isolated showed intra-species diversity of this parasite. This study showed, for the first time, that C. cayetanensis is a pathogen in outpatients with diarrhea in Shanghai, albeit at a low level. However, the transmission dynamics of this parasite in these patients remain uncertain.

Keywords： Cyclospora cayetanensis     outpatients with diarrhea     stool specimens     18S rRNA gene    

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prognostic factors of patients with epithelial ovarian cancer subjected to first-line treatment: a retrospective

Yunfeng Fu, Xinyu Wang, Zimin Pan, Xing Xie

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 91-95 doi: 10.1007/s11684-014-0305-7

Abstract: Univariate analysis revealed that advanced FIGO stage, serum CA125, and suboptimal debulking were significantIn multivariate analysis, PFS was significantly influenced by FIGO stage and suboptimal debulking.

Keywords： ovarian carcinoma     prognostic factors     surgery     chemotherapy     survival    

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cervical high-grade squamous intraepithelial lesion patients with positive margin by conization: a retrospectiveanalysis

Yuya Dou, Xiaodan Zhang, Yang Li, Fenfen Wang, Xing Xie, Xinyu Wang

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 223-228 doi: 10.1007/s11684-017-0517-8

Abstract: Univariate analysis showed that patient age>35 years (P=0.005), menopausal period>5 yearsinvolvement (P=0.001) were significantly correlated with residual disease; however, multivariate analysis

Keywords： cervical high-grade squamous intraepithelial lesion     conization     positive surgical margin     hysterectomy    

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survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results from a retrospective

Frontiers of Medicine   Pages 878-888 doi: 10.1007/s11684-023-0993-y

Abstract: 182 patients with metastatic UM treated with immune checkpoint blockade (ICB) were included in this analysis

Keywords： uveal melanoma     liver-directed therapy     immune checkpoint blockade     SIRT     anti-PD-1     anti-CTLA-4    

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Conservation and adaptive reuse of industrial heritage in Shanghai

ZHANG Song

Frontiers of Structural and Civil Engineering 2007, Volume 1, Issue 4,   Pages 481-490 doi: 10.1007/s11709-007-0065-4

Abstract: This paper takes a retrospective review of the evolution of the conservation of industrial heritage in

Keywords： evolution     industrial     international industrial     retrospective     Shanghai    

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the new maternity insurance scheme on medical expenditures for caesarean delivery in Wuxi, China: a retrospective

Chun Chen,Zhihong Cheng,Ping Jiang,Mei Sun,Qi Zhang,Jun Lv

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 473-480 doi: 10.1007/s11684-016-0479-

Abstract:

Aiming to control rising medical expenditures and help improve China’s healthcare systems, this study examined whether a cap-based medical insurance scheme with shared financial interest between the insurance and healthcare providers is effective in containing hospitals’ C-section medical expenditures. We used 6547 caesarean delivery case records from a teaching tertiary-level general public hospital located in Wuxi, China (2004–2013), and used the Chow test to investigate the possibility of significant variation in mean medical expenditures for caesarean deliveries pre- and post-reform. We also used paired sample t-tests and linear regression models to compare the mean medical expenditures between insured and uninsured women undergoing caesarean delivery during the post-reform period. After the scheme’s implementation, medical expenditures for caesarean deliveries declined and the medical expenditures of women covered by the scheme were significantly lower than those of uninsured patients. These findings indicated the scheme’s effectiveness in minimizing caesarean delivery expenditures. The cap-based medical insurance scheme with shared financial interest between insurance and healthcare providers would likely steer healthcare providers’ behaviors in a more cost-effective direction.

Keywords： maternity insurance scheme     financial incentive     caesarean delivery     medical expenditure     China    

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Clinical laboratory features of Meigs’ syndrome: a retrospective study from 2009 to 2018

Wenwen Shang, Lei Wu, Rui Xu, Xian Chen, Shasha Yao, Peijun Huang, Fang Wang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 116-124 doi: 10.1007/s11684-019-0732-6

Abstract: Meigs’ syndrome (MS), a rare complication of benign ovarian tumors, is easily misdiagnosed as ovarian cancer (OC). We retrospectively reviewed the clinical laboratory data of patients diagnosed with MS from 2009 to 2018. Serum carbohydrate antigen 125 and HE4 levels were higher in the MS group than in the ovarian thecoma-fibroma (OTF) and healthy control groups (all <0.05). However, the serum HE4 levels were lower in the MS group than in the OC group ( <0.001). A routine blood test showed that the absolute counts and percentages of lymphocytes were significantly lower in the MS group than in the OTF and control groups (all <0.05). However, these variables were higher in the MS group than in the OC group (both <0.05). The neutrophil-to-lymphocyte ratio (NLR) was also significantly lower, whereas the lymphocyte-to-monocyte ratio was higher in the MS group than in the OC group (both <0.05). The NLR, platelet-to-lymphocyte ratio, and systemic immune index were significantly higher in the MS group than in the OTF and control groups (all <0.05). The hypoxia-inducible factor-1 mRNA levels were also significantly higher, whereas the glucose transporter 1, lactate dehydrogenase, and enolase 1 mRNA levels were lower in peripheral CD4 T cells obtained preoperatively in a patient with MS than those in patients with OTF, patients with OC, and controls (all <0.05). The expression of these four glucose metabolism genes was preferentially restored to normal levels after the tumor resection of MS ( <0.001). These clinical laboratory features can be useful in improving the preoperative diagnostic accuracy of MS.

Keywords： Meigs’ syndrome     ovarian thecoma-fibroma     NLR (neutrophil to lymphocyte ratio)     CD4+ T cells     glucose metabolism    

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herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospective

Guohua Chen, Wen Su, Jiayao Yang, Dan Luo, Ping Xia, Wen Jia, Xiuyang Li, Chuan Wang, Suping Lang, Qingbin Meng, Ying Zhang, Yuhe Ke, An Fan, Shuo Yang, Yujiao Zheng, Xuepeng Fan, Jie Qiao, Fengmei Lian, Li Wei, Xiaolin Tong

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 752-759 doi: 10.1007/s11684-020-0813-6

Abstract: In this retrospective study, data were collected from 662 patients with severe/critical COVID-19 who

Keywords： COVID-19     CHM     mortality     a retrospective cohort study    

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Development and testing of a weather-based model to determine potential yield losses caused by potato late blight and optimize fungicide application

Alexey FILIPPOV, Maria KUZNETSOVA, Alexander ROGOZHIN, Olga IAKUSHEVA, Valentina DEMIDOVA, Natalia STATSYUK

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 4,   Pages 462-468 doi: 10.15302/J-FASE-2018239

Abstract:

Late blight is one of the most important potato diseases. To minimize yield losses, various protective measures are used including fungicide application. Active use of fungicides results in a contamination of the environment. Therefore, crop protection strategies optimizing the number of treatments are of great interest. Using information about late blight development in an experimental potato field recorded over 30 seasons, a simulator to forecast yield losses caused by the disease was developed based on the number of 5-d periods favorable for reinfection of plants during a vegetation season. The simulator was successfully verified using independent data on the disease development from nine unprotected potato fields in the Netherlands and Germany. The average difference between the calculated and real yield losses did not exceed 5%. Using the simulator and weather data for a period of 2007-2017, yield losses were calculated for several areas of the Bryansk, Tambov, and Orenburg Regions of Russia. The results revealed differences in disease development between these regions and may be used to develop recommendations for a frequency of fungicide applications according to the regional risk of epidemics, leading to a significant reduction in fungicide use.

Keywords： potato     late blight     Phytophthora infestans     yield losses     retrospective analysis     mathematical model    

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Retrospective study of the efficacy and complication of thoracoabdominal incision for nephrectomy: a

Minggen YANG, Xiaokun ZHAO

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 191-196 doi: 10.1007/s11684-009-0026-5

Abstract: This retrospective study was performed to compare the outcome of thoracoabdominal incision flank incisionA case retrospective analysis assessing operation time, perioperative hemorrhage volume, size of tumor

Keywords： surgery     renal tumors     nephrectomy    

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fertility-sparing surgery for non-epithelial ovarian tumors to safely and successfully become pregnant---a Chinese retrospective

Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 509-517 doi: 10.1007/s11684-017-0554-3

Abstract: Univariate analysis suggested that delivery after treatment is related to PFS (P=0.023), whereasCox regression analysis suggested that only histology was associated with PFS and OS (P<0.05

Keywords： malignant germ cell tumors     ovarian sex cord-stromal tumors     fertility-sparing surgery     prognosis     fertility    

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angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in context of COVID-19 outbreak: a retrospectiveanalysis

Jiuyang Xu, Chaolin Huang, Guohui Fan, Zhibo Liu, Lianhan Shang, Fei Zhou, Yeming Wang, Jiapei Yu, Luning Yang, Ke Xie, Zhisheng Huang, Lixue Huang, Xiaoying Gu, Hui Li, Yi Zhang, Yimin Wang, Frederick G. Hayden, Peter W. Horby, Bin Cao, Chen Wang

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 601-612 doi: 10.1007/s11684-020-0800-y

Abstract: We performed a single-center, retrospective analysis of hospitalized adult COVID-19 patients in Wuhan

Keywords： COVID-19     SARS-CoV-2     hypertension     angiotensin-converting enzyme inhibitor     angiotensin II receptor blocker    

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Title Author Date Type Operation

pemetrexed and platinum for elderly patients with advanced non-squamous non-small-cell lung cancer: a retrospectiveanalysis

Journal Article

Aortic aneurysm and chronic disseminated intravascular coagulation: a retrospective study of 235 patients

Yun Zhang,Chen Li,Min Shen,Bao Liu,Xuejun Zeng,Ti Shen

Journal Article

Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center retrospective

Journal Article

infections among diarrheal outpatients in Shanghai: a retrospective case study

Yanyan Jiang, Zhongying Yuan, Guoqing Zang, Dan Li, Ying Wang, Yi Zhang, Hua Liu, Jianping Cao, Yujuan Shen

Journal Article

prognostic factors of patients with epithelial ovarian cancer subjected to first-line treatment: a retrospective

Yunfeng Fu, Xinyu Wang, Zimin Pan, Xing Xie

Journal Article

cervical high-grade squamous intraepithelial lesion patients with positive margin by conization: a retrospectiveanalysis

Yuya Dou, Xiaodan Zhang, Yang Li, Fenfen Wang, Xing Xie, Xinyu Wang

Journal Article

survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results from a retrospective

Journal Article

Conservation and adaptive reuse of industrial heritage in Shanghai

ZHANG Song

Journal Article

the new maternity insurance scheme on medical expenditures for caesarean delivery in Wuxi, China: a retrospective

Chun Chen,Zhihong Cheng,Ping Jiang,Mei Sun,Qi Zhang,Jun Lv

Journal Article

Clinical laboratory features of Meigs’ syndrome: a retrospective study from 2009 to 2018

Wenwen Shang, Lei Wu, Rui Xu, Xian Chen, Shasha Yao, Peijun Huang, Fang Wang

Journal Article

herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospective

Guohua Chen, Wen Su, Jiayao Yang, Dan Luo, Ping Xia, Wen Jia, Xiuyang Li, Chuan Wang, Suping Lang, Qingbin Meng, Ying Zhang, Yuhe Ke, An Fan, Shuo Yang, Yujiao Zheng, Xuepeng Fan, Jie Qiao, Fengmei Lian, Li Wei, Xiaolin Tong

Journal Article

Development and testing of a weather-based model to determine potential yield losses caused by potato late blight and optimize fungicide application

Alexey FILIPPOV, Maria KUZNETSOVA, Alexander ROGOZHIN, Olga IAKUSHEVA, Valentina DEMIDOVA, Natalia STATSYUK

Journal Article

Retrospective study of the efficacy and complication of thoracoabdominal incision for nephrectomy: a

Minggen YANG, Xiaokun ZHAO

Journal Article

fertility-sparing surgery for non-epithelial ovarian tumors to safely and successfully become pregnant---a Chinese retrospective

Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li

Journal Article

angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in context of COVID-19 outbreak: a retrospectiveanalysis

Jiuyang Xu, Chaolin Huang, Guohui Fan, Zhibo Liu, Lianhan Shang, Fei Zhou, Yeming Wang, Jiapei Yu, Luning Yang, Ke Xie, Zhisheng Huang, Lixue Huang, Xiaoying Gu, Hui Li, Yi Zhang, Yimin Wang, Frederick G. Hayden, Peter W. Horby, Bin Cao, Chen Wang

Journal Article